StressCovidV1, Main, Exploration, bibRecord, 001262

Childhood Adversity and Herpesvirus Latency in Breast Cancer Survivors

Identifieur interne : 001262 ( Main/Exploration ); précédent : 001261; suivant : 001263

Childhood Adversity and Herpesvirus Latency in Breast Cancer Survivors

Auteurs : Christopher P. Fagundes [États-Unis] ; Ronald Glaser [États-Unis] ; William B. Malarkey [États-Unis] ; Janice K. Kiecolt-Glaser [États-Unis]

Source :

Health psychology : (Hillsdale, N.J.) [ 0278-6133 ] ; 2013.

RBID : Pascal:13-0175512

Descripteurs français

Pascal (Inist)
- Expérience infantile, Traumatisme infantile, Cancer du sein, Survivant, Stress, Virose, Cytomegalovirus, Virus Epstein Barr, Evénement existentiel, Femelle.

English descriptors

KwdEn :
- Breast cancer, Cytomegalovirus, Early traumatism, Epstein Barr virus, Female, Infantile experience, Life events, Stress, Survivor, Viral disease.

Abstract

Objective: Childhood adversity has been linked to greater emotional and physiological sensitivity to stress. Stress has well-documented effects on cellular immunity, including enhanced herpesvirus reactivation. This study assessed whether childhood adversity was associated with the expression of two latent herpesviruses, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in adults, and whether this association could be detected beyond the psychological distress women experienced in the aftermath of a breast cancer diagnosis and its treatment. Methods: One hundred and eight breast cancer survivors completed questionnaires and provided blood samples to assess EBV virus capsid antigen (VCA) IgG antibody titers and CMV IgG antibody titers. Results: Breast cancer survivors who experienced more childhood adversities had higher EBV and CMV antibody titers than those with fewer childhood adversities. Those who experienced more childhood adversities also had more depressive symptoms, less education, and poorer sleep quality than those with fewer childhood adversities. Depressive symptoms, education, sleep quality, age, BMI, cancer stage, comorbidities, and weekly alcohol consumption were not related to EBV or CMV antibody titers. Time since last treatment was negatively associated with EBV and CMV antibody titers. Elevated antibody titers to latent herpesviruses represent poorer cellular immune system control over viral latency; these data suggest that those with more childhood adversities have poorer cellular immune function. Conclusions: These findings add to the emerging literature suggesting that adverse early experiences may make people more vulnerable to immune dysregulation in adulthood. The consequences of early adversity appear to persist across the life span.

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

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to stream Main, to step Merge: 001264
to stream Main, to step Curation: 001262

Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective: Childhood adversity has been linked to greater emotional and physiological sensitivity to stress. Stress has well-documented effects on cellular immunity, including enhanced herpesvirus reactivation. This study assessed whether childhood adversity was associated with the expression of two latent herpesviruses, Epstein-Barr virus (EBV) and cytomegalovirus (CMV) in adults, and whether this association could be detected beyond the psychological distress women experienced in the aftermath of a breast cancer diagnosis and its treatment. Methods: One hundred and eight breast cancer survivors completed questionnaires and provided blood samples to assess EBV virus capsid antigen (VCA) IgG antibody titers and CMV IgG antibody titers. Results: Breast cancer survivors who experienced more childhood adversities had higher EBV and CMV antibody titers than those with fewer childhood adversities. Those who experienced more childhood adversities also had more depressive symptoms, less education, and poorer sleep quality than those with fewer childhood adversities. Depressive symptoms, education, sleep quality, age, BMI, cancer stage, comorbidities, and weekly alcohol consumption were not related to EBV or CMV antibody titers. Time since last treatment was negatively associated with EBV and CMV antibody titers. Elevated antibody titers to latent herpesviruses represent poorer cellular immune system control over viral latency; these data suggest that those with more childhood adversities have poorer cellular immune function. Conclusions: These findings add to the emerging literature suggesting that adverse early experiences may make people more vulnerable to immune dysregulation in adulthood. The consequences of early adversity appear to persist across the life span.</div>
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Childhood Adversity and Herpesvirus Latency in Breast Cancer Survivors

Childhood Adversity and Herpesvirus Latency in Breast Cancer Survivors

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri